Distribution of Renin in Subcellular Fractions from the Rabbit Kidney
نویسندگان
چکیده
منابع مشابه
Renin content in subcellular fractions of normal rat kidney extract.
glucose-6-phosphatase was determined in order to ascertain the nomenclature of each fraction. Renin content in these extracts as well as the extract of whole kidney was determined. In the subcellular fractions, renin content in lysosomal fraction was 1.10•}0.25ƒÊg, mitochondrial fraction 0.60•}0.12ƒÊg, mitochondrial-microsomal fraction 0.18•}0.01ƒÊg, microsomal fraction 0ƒÊg and soluble fractio...
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Three separate prostaglandin-generating activities are associated with plasma membranes, mitochondria and microsomal fractions from rabbit kidney medulla. In the plasma membranes and mitochondria, but not in microsomal fractions, Ca2+ ions stimulate the activity of phospholipase A2, yielding selective release of arachidonic acid and linoleic acid and concomitant increase in prostaglandin E2 for...
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SUARY Renovascular hypertension was produced in Wistar-King strain female rats by left renal artery clipping. The clipped kidney and the contralateral untouched kidney were cut into cortical, cortico-medullary and medullary portion. The cortical extract was divided into subcellular fractions by the step-wise centrifugation method. Enzyme activity of acid phosphatase, cytochrome C oxidase and gl...
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Immunocytochemical studies have shown that renin, which is normally located in the juxtaglomerular afferent arteriole, may also be found farther upstream toward the interlobular artery during chronic stimulation of the renin-angiotensin system. We assessed the renin distribution along the renal microvasculature using both quantitative analysis and immunocytochemistry in rabbits that received a ...
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A substantial amount of data is available to suggest that lysosomal sequestration of aminoglycoside antibiotics plays a role in the pathogenesis of aminoglycoside-induced renal tubule cell injury; however, relatively little information is available on the subcellular distribution of aminoglycosides in the kidney during treatment protocols of the type that ultimately go on to produce extensive l...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1975
ISSN: 0021-5198
DOI: 10.1254/jjp.25.295